PTGLweb is a web server and database of protein structure topologies [Wolf et al., 2020, Bioinformatics; Koch and Schäfer, 2018, Current Opinion in Structural Biology; Schäfer et al., 2015, Bioinformatics]. PTGLweb is based on topology graphs of different levels of abstraction computed by PTGLtools (formerly labeled VPLG). The graphs can be automated computed, visualized and used for further analysis.
This web server allows you to search for protein motifs which can be detected in the graphs. It also provides standardized 2D visualizations of protein graphs and folding graphs. In contrast to the manually curated CATH and SCOP databases, the method used by this server is fully automated. Similar servers, which also support substructure search, include ProSMoS and Pro-Origami.
PTGL stands for Protein Topology Graph Library. It is a database of protein structure topologies modeled as undirected, labeled graphs. It provides a web server to visualize and analyze protein structure topologies at different scales, e.g., secondary structure level and chain level. The graph computation was done by our software PTGLtools (formerly labeled VPLG). PTGLtools is based on the 3D atomic coordinates from the PDB either as legacy PDB file or as macromolecular Crystallographic Information File (mmCIF). Reading mmCIFs allows processing large protein structures (> 62 chains or > 99,999 atoms). The secondary structure assignment is parsed with small adaptions from a DSSP file.Read more about PTGLweb...
You can find worked out step-by-step examples with screenshots of the output of the following topics: